Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Bromobenzenesulfonyl chloride → Diphenylmethyl 7-Phenoxyacetamido-3-(Z-1-propenyl)-3-cephem-4carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Bromobenzenesulfonyl chloride | HCID 7396 | — |
| 반응물 | (Z)-Tri-n-butyl(1-propenyl)tin | HCID 10914524 | — |
| 반응물 | Diphenylmethyl 7-Phenoxyacetamido-3-[(4-bromophenylsulfonyl)oxy]-3-cephem-4-carboxylate | HCID 88424480 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | Diphenylmethyl 7-Phenoxyacetamido-3-(Z-1-propenyl)-3-cephem-4carboxylate | HCID 14608940 | — |
반응 단계
To a mixture of 0.184 g (0.00025 mole) of the product of Procedure 6, 0.103 g (0.0003215 mole) of Z-1-propenyl-tri-n-butylstannane and 0.0064 g (0.000025 mole) of 4-bromobenzenesulfonyl chloride in 2.5 mL of 1-methyl-2-pyrrolidinone, under a nitrogen atmosphere, at room temperature was added 0.006 g (0.000025 mole) of palladium (II) acetate. The reaction mix was stirred at room temperature for 20 hours. High pressure liquid chromatography (HPLC) analysis of the reaction mixture showed a peak for the title compound with retention time identical to an authentic sample of the title compound. The HPLC area percent for this peak was 21.2%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05245027 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-d423bb0af2d64620abf46421b8a2f7ef |
| 출처 메모 | uspto-grants-1993_09 |