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Isopropanol → Ethyl 3-(5-chloro-2-methoxyphenyl)-2-cyanoacrylate

HRID 554818
노트
인쇄 미리보기

반응식

HRID 554818 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH3:11])=[C:6]([CH:9]=1)[CH:7]=O.[C:12]([O:15][CH2:16][CH2:17][C:18]#[N:19])(=O)[CH3:13].C([OH:23])(C)C>[Cl-].C([N+](CC)(CC)CC1C=CC=CC=1)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH3:11])=[C:6]([CH:7]=[C:17]([C:18]#[N:19])[C:16]([O:15][CH2:12][CH3:13])=[O:23])[CH:9]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 3776IsopropanolHCID 2192242-Cyanoethyl acetateHCID 37183565-Chloro-2-methoxybenzaldehyde

생성물 1

HCID 47301778Ethyl 3-(5-chloro-2-methoxyphenyl)-2-cyanoacrylate

시약·촉매·용매 1

HCID 66133Benzyl triethylammonium chloride촉매

반응 조건

온도
80 °C

실험 절차

A mixture of 5-chloro-2-methoxybenzaldehyde (32.2 g), cyanoethyl acetate and triethylbenzyl ammonium chloride (8.6 g) was stirred at 80° C. for 7 hours. To the reaction solution, isopropyl alcohol (97 ml) was added, then the mixture was stirred under ice cooling for 1 hour. The precipitated crystals were collected by filtration and dried in vacuo to obtain the title compound in an amount of 42.7 g as crystals.

후처리

  1. stirringthe mixture was stirred under ice cooling for 1 hour
  2. filtrationThe precipitated crystals were collected by filtration
  3. customdried in vacuo

출처 및 근거

ORD 기록
ord-f325eca91b844936a50392e4b074a390
출처 데이터셋
uspto-grants-2011_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08049006B2

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