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FC1[CH:23]=[CH:22][C:5]([CH2:6][N:7]2[C:11](=[O:12])[N:10]([C:13]3[S:14][C:15]([C:19]([OH:21])=O)=[C:16]([CH3:18])[N:17]=3)[CH:9]=[N:8]2)=CC=1.C1(C[N:28]2C(=O)N(C3SC(C(O)=O)=C(C)N=3)C=N2)CC1>>[CH:5]1([CH2:6][N:7]2[C:11](=[O:12])[N:10]([C:13]3[S:14][C:15]([C:19]([NH2:28])=[O:21])=[C:16]([CH3:18])[N:17]=3)[CH:9]=[N:8]2)[CH2:22][CH2:23]1참가 물질
3
실험 절차
Following the procedure as described in Example 1, making variations as required to replace 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid with 2-(1-(cyclopropylmethyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-4-methylthiazole-5-carboxylic acid, the title compound was obtained as an off-white solid in 43% yield: mp 180-181° C. (ethanol/water); 1H NMR (300 MHz, DMSO-d6) δ 8.73 (s, 1H), 7.63 (br, 2H), 3.66 (d, J=7.0 Hz, 2H), 2.55 (s, 3H), 1.21-1.11 (m, 1H), 0.54-0.48 (m, 2H), 0.38-0.32 (m, 2H); 13C NMR (75 MHz, DMSO-d6) δ 162.6, 151.3, 150.9, 149.5, 131.4, 122.9, 49.4, 16.8, 10.0, 3.3; MS (ES+) m/z 280.3 (M+1).
출처 및 근거
- ORD 기록
- ord-16c5e4193de34527b4f4036f6ca20617
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08049016B2
연결된 노트
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