Glycolic Acid → HCID 178519921, 화합물

반응식

[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[C:10](O)(=O)[CH2:11][OH:12]>>[Br:1][C:2]1[CH:3]=[C:4]2[N:9]=[C:10]([CH2:11][OH:12])[NH:8][C:5]2=[N:6][CH:7]=1

참가 물질

반응물 2

HCID 757Glycolic Acid

HCID 6911565-Bromopyridine-2,3-diamine

생성물 1

HCID 178519921HCID 178519921, 화합물

실험 절차

A procedure similar to that described in Preparation 43 was repeated, except that 7.00 g of 5-bromo-2,3-diaminopyridine (prepared as described in Preparation 57) and 8.50 g of glycolic acid were used, to give the title compound as a crude product. This crude product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 7.05 g of the title compound, melting at 230°-233° C.

후처리

customA procedure similar to that described in Preparation 43

출처 및 근거

ORD 기록: ord-258830a8cec74256ae7bf551b8976fb9
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05624935

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