Aniline → 3-nitro-N-phenylpyridin-2-amine

HRID 55525노트

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HRID 55525 반응식
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[Na+].[Na+]>C1(C)C=CC=CC=1>[N+:8]([C:7]1[C:2]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

참가 물질

5

반응물 3

HCID 6115AnilineHCID 10340Sodium CarbonateHCID 796132-Chloro-3-nitropyridine

생성물 1

HCID 6117993-nitro-N-phenylpyridin-2-amine수율 33.9%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A procedure similar to that described in Preparation 66 was repeated, except that 15 g of 2-chloro-3-nitropyridine, 13.22 g of aniline and 25.07 g of sodium carbonate were reacted in 180 ml of toluene. After working up the product as described in preparation 66, the resulting crude product was purified by column chromatography through silica gel, using a 1:5 by volume mixture of ethyl acetate and hexane, to give 6.9 g of the title compound, melting at 66°-68° C.

후처리

  1. customA procedure similar to that described in Preparation 66
  2. customas described in preparation 66
  3. customthe resulting crude product was purified by column chromatography through silica gel
  4. additionby volume mixture of ethyl acetate and hexane

출처 및 근거

ORD 기록
ord-ab03cc8e9cd849c6beb1ad0b306157dd
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05624935

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