(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate → (+/-)-1-Oxiranylmethyl-4-(3-phenyl-propyl)-piperazine

HRID 555308

반응식

HRID 555308 반응식
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:16]1[CH2:18][CH:17]1[CH2:19]OS(C1C=CC=C([N+]([O-])=O)C=1)(=O)=O>>[O:16]1[CH2:18][CH:17]1[CH2:19][N:13]1[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:15][CH2:14]1

참가 물질

3

반응물 2

HCID 286836(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonateHCID 7965341-(3-Phenylpropyl)piperazine

생성물 1

HCID 17810519(+/-)-1-Oxiranylmethyl-4-(3-phenyl-propyl)-piperazine수율 80%

실험 절차

The same method as employed in the preparation of Intermediate 1 but starting from 1-(3-phenylpropyl)-piperazine and 3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after Biotage chromatography the title compound as a yellow oil in a 80% yield.

출처 및 근거

ORD 기록
ord-a7606830c6ef40fa8c593f3e47f355cc
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053436B1

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