참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Naphthyl Isothiocyanate | HCID 11080 | — |
| 반응물 | 2-(2-tert-Butylphenoxy)pyridin-3-amine | HCID 28605427 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | HCID 59857370 | HCID 59857370 | — |
반응 단계
A solution of 1b (40 mg, 0.17 mmol) and 1-naphtylisothiocyanate (34 mg, 0.18 mmol) in dioxane (2 mL) was heated at 60° C. for 6 h. More 1-naphtylisothiocyanate (34 mg, 0.18 mmol) was added and the mixture was heated at 60° C. for 8 days. The mixture was concentrated and the residue was purified by column chromatography on silica gel using a continuous gradient from 0% to 40% ethyl acetate in hexanes as eluent to afford 102a which was directly used in the next step. [M−H]−=426.18.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08053450B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-ff6f066617144174b7fa06cc4e5ab556 |
|---|
| 출처 메모 | uspto-grants-2011_11 |
|---|
