Thiocarbonyl diimidazole → 6-(2-tert-butylphenoxy)-5-isothiocyanato-N-methylpyridin-2-amine

참여 물질

반응 조건

반응 단계

A solution of 136d (16.28 mg, 0.0600 mmol) in anhydrous DCM (1.0 mL) was added dropwise to a cold solution of thiocarbonyl diimidazole (21.39 mg, 0.1200 mmol) in anhydrous DCM (0.50 mL). The reaction was stirred at 0° C. for 1 h and then warmed to rt with stirring for 2 h. The mixture was concentrated down and the residue was flushed through a plug of silica gel with 10% EtOAc in hexanes. Concentration of the eluent afforded 136e.

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