Piperidine → 3-((5-(hydroxymethyl)furan-2-yl) methylene)-N-acetyl-2-oxoindoline

HRID 555665

반응식

HRID 555665 반응식
[C:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][C:5]1=[O:13])(=[O:3])[CH3:2].O[CH2:15][C:16]1[O:20][C:19]([CH:21]=[O:22])=[CH:18][CH:17]=1.N1CCCCC1>C(O)C>[OH:22][CH2:21][C:19]1[O:20][C:16]([CH:15]=[C:6]2[C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[N:4]([C:1](=[O:3])[CH3:2])[C:5]2=[O:13])=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 8082PiperidineHCID 2373325-(Hydroxymethyl)furfuralHCID 3237191-Acetylindolin-2-one

생성물 1

HCID 669866263-((5-(hydroxymethyl)furan-2-yl) methylene)-N-acetyl-2-oxoindoline

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

N-acetyloxindole (1 equivalent), 5-hydroxymethyl-2-furaldehyde (0.5 equivalent) and piperidine (0.2 equivalent) were dissolved in ethanol such that 1 mL of ethanol was used per 1 μmol of the total amount of the compounds, and the resulting mixture was stirred at room temperature for 12 hours. After completion of the reaction, the resulting precipitate was collected by filtration, washed with cooled ethanol several times and dried, whereby 3-((5-(hydroxymethyl)furan-2-yl) methylene)-N-acetyl-2-oxoindoline was obtained.

후처리

  1. customAfter completion of the reaction
  2. filtrationthe resulting precipitate was collected by filtration
  3. washwashed with cooled ethanol several times
  4. customdried

출처 및 근거

ORD 기록
ord-d681d2db206c4d6eadb06b44412df9dd
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053461B2

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