Ethyl 4-(benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylate → Ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate

HRID 555675

반응식

HRID 555675 반응식
C(OC([NH:11][C:12]12[CH2:19][CH2:18][C:15]([C:20]([O:22][CH2:23][CH3:24])=[O:21])([CH2:16][CH2:17]1)[CH2:14][CH2:13]2)=O)C1C=CC=CC=1.[H][H]>C(O)C.[C].[Pd]>[NH2:11][C:12]12[CH2:17][CH2:16][C:15]([C:20]([O:22][CH2:23][CH3:24])=[O:21])([CH2:14][CH2:13]1)[CH2:18][CH2:19]2

참가 물질

5

반응물 2

HCID 10616503Ethyl 4-(benzyloxycarbonylamino)bicyclo[2.2.2]octane-1-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 23149693Ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate수율 100.4%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

Ethyl 4-benzyloxycarbonylaminobicyclo[2.2.2]octane-1-carboxylate (40.0 g) was dissolved in ethanol (400 mL). To this solution, 10% palladium-carbon (4.00 g) was added and the mixture was stirred at room temperature for 6 hours in a stream of hydrogen. The catalyst in the reaction mixture was filtered through a Celite pad and the filtered catalyst, together with the Celite pad, was washed with ethanol. The filtrate and the washings were combined and concentrated under reduced pressure. The resulting residue was dried under reduced pressure to give ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylate (23.9 g).

후처리

  1. filtrationThe catalyst in the reaction mixture was filtered through a Celite pad
  2. washthe filtered catalyst, together with the Celite pad, was washed with ethanol
  3. concentrationconcentrated under reduced pressure
  4. customThe resulting residue was dried under reduced pressure

출처 및 근거

ORD 기록
ord-2b82e76f8a234554b2fedbe45a240614
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053465B2

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