Potassium Carbonate → [4-(2-Imidazol-1-yl-ethyl)-piperazin-1-yl]acetonitrile

HRID 555730노트

반응식

HRID 555730 반응식
[N:1]1([CH2:6][CH2:7][N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:4][N:3]=[CH:2]1.Br[CH2:15][C:16]#[N:17].C([O-])([O-])=O.[K+].[K+]>CC#N>[N:1]1([CH2:6][CH2:7][N:8]2[CH2:9][CH2:10][N:11]([CH2:15][C:16]#[N:17])[CH2:12][CH2:13]2)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 11534BromoacetonitrileHCID 27593491-(2-Imidazol-1-yl-ethyl)-piperazine

생성물 1

HCID 86641785[4-(2-Imidazol-1-yl-ethyl)-piperazin-1-yl]acetonitrile

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 1-(2-Imidazol-1-yl-ethyl)-piperazine (commercially available from CHESS GmbH) (1.0 g, 5.44 mmol), bromoacetonitrile (740 mg, 6.0 mmol) and K2CO3 (1.65 g, 12.0 mmol) in CH3CN (15 mL) is stirred at RT. After completion the product is isolated by filtration with Celite and washed with CH3CN and dried under reduced pressure to give the title compound as oil; ES-MS: M+H=220.2: CtRet=1.70.

후처리

  1. customAfter completion the product is isolated by filtration with Celite
  2. washwashed with CH3CN
  3. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-5e63030a66e846a797aa9808e31403b4
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053457B2

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