Bromoacetonitrile → (4-Adamantan-1-yl-piperazin-1-yl)-acetonitrile

HRID 555756

반응식

HRID 555756 반응식
[C:1]12([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.Br[CH2:18][C:19]#[N:20]>>[C:1]12([N:11]3[CH2:16][CH2:15][N:14]([CH2:18][C:19]#[N:20])[CH2:13][CH2:12]3)[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2

참가 물질

3

반응물 2

HCID 11534BromoacetonitrileHCID 35373Piperazine, 1-(1-adamantyl)-

생성물 1

HCID 84083703(4-Adamantan-1-yl-piperazin-1-yl)-acetonitrile

실험 절차

The title compound is synthesized by coupling of 1-Adamantyl-piperazine (commercially available from CHESS GmbH) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=260.3: 1HNMR(DMSO-d6) 3.65 (s, 2H), 2.60-2.50 (m, 4H), 2.45-2.40 (m, 4H), 2.00 (bs, 3H), 1.60-1.50 (m, 12H).

후처리

  1. customanalogously to the preparation of Intermediate 149.2 as a colorless oil

출처 및 근거

ORD 기록
ord-99a1dbb36f5348458110d9cde561c6c1
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053457B2

연결된 노트

불러오는 중…