Bromoacetonitrile → 2-(4-Benzylpiperidin-1-yl)acetonitrile

반응식

[CH2:1]([CH:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:15][C:16]#[N:17]>>[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH2:15][C:16]#[N:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 11534Bromoacetonitrile

HCID 317384-Benzylpiperidine

생성물 1

HCID 106801642-(4-Benzylpiperidin-1-yl)acetonitrile

실험 절차

The title compound is synthesized by coupling of 4-Benzyl-piperidine and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=215.2: AtRet=2.90.

출처 및 근거

ORD 기록: ord-3e069f62b67546579bcf890c86dc2e52
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08053457B2

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