Bromoacetonitrile → HCID 86641792, 화합물

반응식

[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:3][CH2:2]1.Br[CH2:15][C:16]#[N:17]>>[N:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[CH2:7][CH:4]1[CH2:5][CH2:6][N:1]([CH2:15][C:16]#[N:17])[CH2:2][CH2:3]1

참가 물질

반응물 2

HCID 11534Bromoacetonitrile

HCID 38006202-[(Piperidin-4-yl)methyl]pyridine

생성물 1

HCID 86641792HCID 86641792, 화합물

실험 절차

The title compound is synthesized by coupling of 2-Piperidin-4-ylmethyl-pyridine (commercially available from Array Biopharma) and bromoacetonitrile analogously to the preparation of Intermediate 149.2 as a colorless oil; ES-MS: M+=216.2.

후처리

customanalogously to the preparation of Intermediate 149.2 as a colorless oil

출처 및 근거

ORD 기록: ord-8c6225c6fee1424f8f8377ef533024da
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08053457B2

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