4-Methoxycyclohexanol (cis,trans) → 4-Methoxycyclohexanone

HRID 555831

반응식

HRID 555831 반응식
[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][CH:6]([OH:9])[CH2:5][CH2:4]1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1>C(Cl)Cl>[CH3:1][O:2][CH:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1

참가 물질

4

반응물 2

HCID 1403324-Methoxycyclohexanol (cis,trans)HCID 178418287HCID 178418287, 화합물

생성물 1

HCID 5350284-Methoxycyclohexanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-Methoxycyclohexanol (2.0 g, 15.0 mmol) was taken up in 150 mL of DCM. Pyridinium chlorochromate (5.0 g, 23.0 mmol) was added. After 60 hours, the mixture was filtered through a plug of Florisil and concentrated under reduced pressure. The residue was taken up in 50 mL of ether and filtered through a plug of silica gel. The solvent was removed under reduced pressure, affording 4-methoxycyclohexanone as a light yellow oil.

후처리

  1. filtrationthe mixture was filtered through a plug of Florisil
  2. concentrationconcentrated under reduced pressure
  3. filtrationfiltered through a plug of silica gel
  4. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-f507dd16125c411db6001cdd6e80706a
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053438B2

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