(Diethylamino)sulfur trifluoride → 2-Fluoro-3-(4-fluorotetrahydro-2H-pyran-4-YL)pyrazine

HRID 555859노트

반응식

HRID 555859 반응식
[F:1][C:2]1[C:3]([C:8]2(O)[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][N:7]=1.CCN(S(F)(F)[F:21])CC>C(Cl)Cl>[F:1][C:2]1[C:3]([C:8]2([F:21])[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)=[N:4][CH:5]=[CH:6][N:7]=1

참가 물질

4

반응물 2

HCID 123472(Diethylamino)sulfur trifluorideHCID 593512304-(3-Fluoropyrazin-2-YL)tetrahydro-2H-pyran-4-OL

생성물 1

HCID 593511352-Fluoro-3-(4-fluorotetrahydro-2H-pyran-4-YL)pyrazine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-(3-fluoropyrazin-2-yl)tetrahydro-2H-pyran-4-ol (0.123 g, 0.621 mmol) in DCM (2 mL) cooled to 0° C. was added dropwise dast (0.164 mL, 1.241 mmol). The resulting mixture was stirred for 2 hr. Reaction was quenched with dropwise addition of saturated NaHCO3 solution and back extracted with DCM to produce product.

후처리

  1. customReaction
  2. customwas quenched with dropwise addition of saturated NaHCO3 solution
  3. extractionback extracted with DCM
  4. customto produce product

출처 및 근거

ORD 기록
ord-f6d5830ddd86440fa0af1512dadf484c
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053438B2

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