2-(2-Ethyl-2h-tetrazol-5-yl)-ethylamine → 1-(6-Bromo-imidazo[1,2-a]pyridin-2-yl)-3-[2-(2-ethyl-2h-tetrazol-5-yl)-ethyl]-urea

HRID 555981노트

반응식

HRID 555981 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:12]([NH:14][CH2:15][CH2:16][C:17]3[N:18]=[N:19][N:20]([CH:22](C)[CH3:23])[N:21]=3)=[O:13])[N:10]=2)[CH:7]=1.Cl.C(N1N=NC(CCN)=N1)(C)C.C(N1N=NC(CCN)=N1)C>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([NH:11][C:12]([NH:14][CH2:15][CH2:16][C:17]3[N:18]=[N:19][N:20]([CH2:22][CH3:23])[N:21]=3)=[O:13])[N:10]=2)[CH:7]=1

참가 물질

4

반응물 3

HCID 552855002-(2-Ethyl-2h-tetrazol-5-yl)-ethylamine2회HCID 592518731-(6-Bromo-imidazo[1,2-a]pyridin-2-yl)-3-[2-(2-isopropyl-2H-tetrazol-5-yl)-ethyl]-ureaHCID 669862432-(2-isopropyl-2H-tetrazol-5-yl)-ethylamine hydrochloride

생성물 1

HCID 251744911-(6-Bromo-imidazo[1,2-a]pyridin-2-yl)-3-[2-(2-ethyl-2h-tetrazol-5-yl)-ethyl]-urea

실험 절차

This compound is prepared analogously to Intermediate E1 (described in preparation of intermediates section) by replacing 2-(2-isopropyl-2H-tetrazol-5-yl)-ethylamine hydrochloride (Intermediate D1) with 2-(2-ethyl-2H-tetrazol-5-yl)-ethylamine (Intermediate D2).

출처 및 근거

ORD 기록
ord-3756083e3e7943c4b45912e910617685
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053574B2

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