Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diazomethane → Methyl 4-(2-furyl)-3-oxaoctanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diazomethane | HCID 9550 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 4-(2-Furyl)-3-oxaoctanoic acid | HCID 19796008 | — |
| 반응물 | N-Methyl-N'-nitro-N-nitrosoguanidine | HCID 135436526 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Methyl 4-(2-furyl)-3-oxaoctanoate | HCID 20093102 | — |
반응 단계
Crude acid from example 84 (25 g, 118 mmol) was dissolved in ether and treated with excess diazomethane (generated by adding 1-methyl-3-nitro-1-nitrosoguanidine (MNNG) to a mixture of 40% KOH (aq) and ether at 0° C.). Excess diazomethane was quenched with acetic acid after 30 m. Vacuum distillation gave 18.8 g (70%): [α]25D -100°; bp 100°-109° C. (0.5 mmHg); 1H NMR (300 MHz, CDCl3) δ 7.40 (1H, dd, J=1 Hz), 6.34 (1H, dd, J=1 Hz), 6.29 (1H, dd, J=1 Hz), 4.43 (1H, t, J=7 Hz), 4.00 (2H, q, J=16 Hz), 3.72 (3H, s), 1.92 (2H, m), 1.33 (4H, m), 0.89 (3H, t, J=7 Hz); mass spectrum (FAB): 244 (M+NH4).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05244910 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-98ddb6a92a0a4ff7b45cdbe2ae30430c |
| 출처 메모 | uspto-grants-1993_09 |