Pyridine → 1,8-Bis[2-(Isobutylamino)Acetamido]Anthraquinone

HRID 556199노트

반응식

HRID 556199 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23]Cl)[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4].[N:27]1[CH:32]=[CH:31][CH:30]=CC=1.[CH2:33]([NH2:37])[CH:34]([CH3:36])[CH3:35].[CH3:38]N(C)C=O>>[CH2:33]([NH:37][CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23][NH:27][CH2:32][CH:31]([CH3:30])[CH3:38])[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4])[CH:34]([CH3:36])[CH3:35]

참가 물질

5

반응물 4

HCID 1049PyridineHCID 6228DimethylformamideHCID 6558IsobutylamineHCID 469280411,8-Bis(chloroacetamido)anthraquinone2회

생성물 1

HCID 462447741,8-Bis[2-(Isobutylamino)Acetamido]Anthraquinone수율 40%

실험 절차

Add 0.4 g, 1.0 mmol 1,8-bis(chloroacetamido)anthraquinone (compound 3) with pyridine (0.5 ml), and 0.6 ml, 6 mmole Isobutylamine, dissolved in 20 ml dehydrated dimethylformamide (DMF). The mixture is reacted in a mini-reactor. The reaction temperature is 120° C. in the oil bath and the reaction time is 30 minutes. The reacted mixture is poured into 50 ml ice water and is filtered to collect precipitate. The precipitate is recrystallized from ethanol to get yellow compound 3k.

후처리

  1. customThe mixture is reacted in a mini-reactor
  2. customis 120° C. in the oil bath
  3. filtrationis filtered
  4. customto collect precipitate
  5. customThe precipitate is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-00e4a8deecdb438ead2a29856169bd86
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053583B2

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