Pyridine → 1,8-Bis[2-(diethylamino)acetamido]anthraquinone

HRID 556200

반응식

HRID 556200 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23]Cl)[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4].[N:27]1[CH:32]=[CH:31]C=[CH:29][CH:28]=1.[CH2:33]([NH:35][CH2:36][CH3:37])[CH3:34]>CN(C)C=O>[CH2:32]([N:27]([CH2:28][CH3:29])[CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23][N:35]([CH2:36][CH3:37])[CH2:33][CH3:34])[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4])[CH3:31]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 8021DiethylamineHCID 469280411,8-Bis(chloroacetamido)anthraquinone2회

생성물 1

HCID 462447751,8-Bis[2-(diethylamino)acetamido]anthraquinone수율 70%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Add 0.4 g, 1.0 mmol 1,8-bis(chloroacetamido)anthraquinone (compound 3) with pyridine (0.5 ml), and 0.6 ml, 6 mmole Diethylamine, dissolved in 20 ml dehydrated dimethylformamide (DMF). The mixture is reacted in a mini-reactor. The reaction temperature is 120° C. in the oil bath and the reaction time is 30 minutes. The reacted mixture is poured into 50 ml ice water and is filtered to collect precipitate. The precipitate is recrystallized from ethanol to get yellow compound 3l.

후처리

  1. customThe mixture is reacted in a mini-reactor
  2. customis 120° C. in the oil bath
  3. filtrationis filtered
  4. customto collect precipitate
  5. customThe precipitate is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-7fa87425d52c47a5b3831c9a71c45e7e
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053583B2

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