3-(Trifluoromethyl)benzylamine → 1,8-Bis[2-(3-(trifluoromethyl)benzylamino)acetamido]anthraquinone

HRID 556204

반응식

HRID 556204 반응식
Cl[CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23]Cl)[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4].[F:27][C:28]([F:38])([F:37])[C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][CH:36]=1)[CH2:32][NH2:33]>CN(C)C=O>[F:27][C:28]([F:37])([F:38])[C:29]1[CH:30]=[C:31]([CH:34]=[CH:35][CH:36]=1)[CH2:32][NH:33][CH2:2][C:3]([NH:5][C:6]1[C:19]2[C:18](=[O:20])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][C:16]=3[NH:21][C:22](=[O:25])[CH2:23][NH:33][CH2:32][C:31]3[CH:34]=[CH:35][CH:36]=[C:29]([C:28]([F:27])([F:37])[F:38])[CH:30]=3)[C:11](=[O:26])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:4]

참가 물질

4

반응물 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 469280411,8-Bis(chloroacetamido)anthraquinone2회

생성물 1

HCID 462448671,8-Bis[2-(3-(trifluoromethyl)benzylamino)acetamido]anthraquinone수율 66%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Add 0.4 g, 1.0 mmol 1,8-bis(chloroacetamido)anthraquinone (compound 3) with 0.5 ml TEA, and 0.8 ml, 6 mmole 3-(trifluoromethyl)benzylamine, dissolved in 20 ml dehydrated dimethylformamide (DMF). The mixture is reacted in a mini-reactor. The reaction temperature is 120° C. in the oil bath and the reaction time is 30 minutes. The reacted mixture is poured into 50 ml ice water and is filtered to collect precipitate. The precipitate is recrystallized from ethanol to get yellow compound 3q.

후처리

  1. customThe mixture is reacted in a mini-reactor
  2. customis 120° C. in the oil bath
  3. filtrationis filtered
  4. customto collect precipitate
  5. customThe precipitate is recrystallized from ethanol

출처 및 근거

ORD 기록
ord-dcdf01d4164643e8bda450bca40cd54e
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08053583B2

연결된 노트

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