Potassium Hydroxide → 3-{4-[3-(3,4-Difluoro-phenyl)-3-oxo-propenyl]-phenyl}-acrylic acid tert-butyl ester

HRID 556281

반응식

HRID 556281 반응식
[C:1]([O:5][C:6](=[O:17])[CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=O)=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[K+].[CH3:20][C:21]([C:23]1[CH:28]=[CH:27][C:26]([F:29])=[C:25]([F:30])[CH:24]=1)=[O:22]>C(O)C.O.O>[C:1]([O:5][C:6](=[O:17])[CH:7]=[CH:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]=[CH:20][C:21]([C:23]2[CH:28]=[CH:27][C:26]([F:29])=[C:25]([F:30])[CH:24]=2)=[O:22])=[CH:11][CH:10]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

6

반응물 3

HCID 14797Potassium HydroxideHCID 1230521-(3,4-Difluorophenyl)ethan-1-oneHCID 541476044-Formylcinnamic acid tert-butyl ester

생성물 1

HCID 669921713-{4-[3-(3,4-Difluoro-phenyl)-3-oxo-propenyl]-phenyl}-acrylic acid tert-butyl ester수율 88.6%

시약·촉매·용매 2

HCID 962Water용매HCID 19096565Water ethanol용매

실험 절차

3-(4-formyl-phenyl)-acrylic acid tert-butyl ester (150 mg, 0.64 mmol) and KOH (72 mg, 1.28 mmol)) were dissolved in ethanol/water (1:1, 5 ml) and 3,4-difluoroacetophenone (83.2 μl, 0.64 mmol) was added to the resulting solution. The resulting mixture was stirred at room temperature overnight and then diluted with H2O. The precipitate was filtered and dried under vacuo to give 210 mg of 3-{4-[3-(3,4-difluoro-phenyl)-3-oxo-propenyl]-phenyl}-acrylic acid tert-butyl ester.

후처리

  1. filtrationThe precipitate was filtered
  2. customdried under vacuo

출처 및 근거

ORD 기록
ord-ecf5a6c5d0f549968aedb114fe1e385a
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058273B2

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