Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → 4-Phenyl-2-pyridinecarbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Phenylpyridine-1-oxide | HCID 70803 | — |
| 반응물 | Trimethylsilyl cyanide | HCID 82115 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Phenyl-2-pyridinecarbonitrile | HCID 87758 | — |
반응 단계
To a solution of 4-phenylpyridine N-oxide (5 g) in DCM (50 mL) was added at RT trimethylsilylcyanide (11 mL), followed by acetyl chloride (3.1 mL) over 10 min. The reaction mixture was stirred overnight at RT. A solution of aq. 10% Na2CO3 was added and the mixture was extracted with EA. The combined org. phases were washed with brine, dried (Na2SO4) and evaporated off. Filtration over a plug of silica gel (Hept/EA 1/1) gave the desired compound (450 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08058263B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-9c430b76a63140548e31507170d80bec |
| 출처 메모 | uspto-grants-2011_11 |