Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-Amino-6-(3,4-dimethoxyphenyl)-4-methyl-thieno[2,3-b]pyridine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Chloroacetamide | HCID 6580 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | 2-Mercapto-6-(3,4-dimethoxyphenyl)-4-methyl-pyridine-3-carbonitrile | HCID 178488562 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-Amino-6-(3,4-dimethoxyphenyl)-4-methyl-thieno[2,3-b]pyridine-2-carboxamide | HCID 57503714 | 94.3% |
반응 단계
2.1 g (31.4 mmol) sodium ethylate are dissolved in 40 ml absolute ethanol. 3.0 g (10.5 mmol) 2-mercapto-6-(3,4-dimethoxyphenyl)-4-methyl-pyridine-3-carbonitrile and 1.2 g (12.6 mmol) 2-chloroacetamide are added and refluxed for 1 h. Following cooling, 10 ml water are added and the precipitate is sucked off, suck dried and dried in vacuo at 50° C. 3.4 g (94%) 3-amino-6-(3,4-dimethoxyphenyl)-4-methyl-thieno[2,3-b]-pyridine-2-carboxamide is obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08058285B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-cc6d5dd4b1c04f09a1b1427ba0e48989 |
| 출처 메모 | uspto-grants-2011_11 |