Sodium ethoxide → 2-Chloro-4-ethoxy-9-methyl-7-phenyl-pyrido[3',2':4,5]furo[3,2-d]pyrimidine

HRID 556419노트

반응식

HRID 556419 반응식
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[O:10][C:9]3[N:11]=[C:12]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:13]=[C:14]([CH3:15])[C:8]=3[C:6]=2[N:7]=1.[CH3:23][CH2:24][O-:25].[Na+]>C(O)C>[Cl:1][C:2]1[N:3]=[C:4]([O:25][CH2:24][CH3:23])[C:5]2[O:10][C:9]3[N:11]=[C:12]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH:13]=[C:14]([CH3:15])[C:8]=3[C:6]=2[N:7]=1

참가 물질

4

반응물 2

HCID 2723922Sodium ethoxideHCID 597550892,4-Dichloro-9-methyl-7-phenyl-pyrido[3',2':4,5]furo-[3,2-d]pyrimidine

생성물 1

HCID 231092842-Chloro-4-ethoxy-9-methyl-7-phenyl-pyrido[3',2':4,5]furo[3,2-d]pyrimidine수율 46.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

0.2 g (0.6 mmol) 2,4-dichloro-9-methyl-7-phenyl-pyrido[3′,2′:4,5]furo-[3,2-d]pyrimidine and 0.12 g (1.8 mmol) sodium ethylate are added by stirring into 50 ml absolute ethanol at room temperature for 24 h. Then, the precipitate is sucked off, washed with about 40 ml water and dried. Following flash chromatography, 94 mg (46%) 2-chloro-4-ethoxy-9-methyl-7-phenyl-pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine is obtained.

후처리

  1. washwashed with about 40 ml water
  2. customdried

출처 및 근거

ORD 기록
ord-486e218715d646f683e1c05cd518a7ab
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058285B2

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