2-Fluorophenylboronic acid → HCID 10292840, 화합물

HRID 556546

반응식

HRID 556546 반응식
Cl[C:2]1[C:7]([CH:8]=[O:9])=[C:6]([NH:10][C:11]2[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=2[F:18])[N:5]=[C:4]([S:19][CH3:20])[N:3]=1.[F:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1B(O)O>>[F:18][C:12]1[CH:13]=[CH:14][CH:15]=[C:16]([F:17])[C:11]=1[NH:10][C:6]1[C:7]([CH:8]=[O:9])=[C:2]([C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=2[F:21])[N:3]=[C:4]([S:19][CH3:20])[N:5]=1

참가 물질

3

반응물 2

HCID 27343542-Fluorophenylboronic acidHCID 99447374-Chloro-6-((2,6-difluorophenyl)amino)-2-(methylthio)pyrimidine-5-carbaldehyde

생성물 1

HCID 10292840HCID 10292840, 화합물

실험 절차

Prepared as described above in Example 11 starting from 4-chloro-6-(2,6-difluoro-phenylamino)-2-methylsulfanyl-pyrimidine-5-carbaldehyde and 2-fluorophenylboronic acid to give the title compound 4-(2,6-difluoro-phenylamino)-6-(2-fluoro-phenyl)-2-methylsulfanyl-pyrimidine-5-carbaldehyde. 1H-NMR: δ0.31 (s, 3H), 6.98-7.20 (m, 3H), 7.26 (m, 2H), 7.38-7.42 (m, 2H), 9.79 (s, 1H), 10.39 (br s, 1H). LC MS (m/e)=376 (MH+).

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-0f3e71333f0b4894836f896501939f00
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058282B2

연결된 노트

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