Dimethylamine → HCID 59639578, 화합물

HRID 556644노트

반응식

HRID 556644 반응식
[CH3:1][NH:2][CH3:3].C[Al](C)C.[F:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[C:10]=1[N:16]1[C:21]2[N:22]=[C:23]([NH:34][CH2:35][C:36]([O:38]C)=O)[N:24]=[C:25]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=3[CH3:33])[C:20]=2[CH:19]=[CH:18][C:17]1=[O:40]>>[F:15][C:11]1[CH:12]=[CH:13][CH:14]=[C:9]([F:8])[C:10]=1[N:16]1[C:21]2[N:22]=[C:23]([NH:34][CH2:35][C:36]([N:2]([CH3:3])[CH3:1])=[O:38])[N:24]=[C:25]([C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=3[CH3:33])[C:20]=2[CH:19]=[CH:18][C:17]1=[O:40]

참가 물질

4

반응물 3

HCID 674DimethylamineHCID 16682925TrimethylaluminumHCID 59639612HCID 59639612, 화합물

생성물 1

HCID 59639578HCID 59639578, 화합물수율 54.5%

실험 절차

Following the general procedure outlined in Example 193, dimethylamine (1.1 mL, 2.2 mmol), trimethylaluminum (1.1 mL, 2.2 mmol) and the product of Example 190 (100 mg, 0.22 mmol) were reacted to give the desired product 56 mg (54%). LC-MS: 468.2 (MH+, m/z), 2.00 (Rt, min).

출처 및 근거

ORD 기록
ord-88e0926b81b14dcd90a81d106177ff54
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058282B2

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