Cyclopropylamine → HCID 59639540, 화합물

HRID 556650노트

반응식

HRID 556650 반응식
[CH:1]1([NH2:4])[CH2:3][CH2:2]1.C[Al](C)C.[F:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:11]=1[N:17]1[C:22]2[N:23]=[C:24]([NH:35][CH2:36][C:37](OC)=[O:38])[N:25]=[C:26]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=3[CH3:34])[C:21]=2[CH:20]=[CH:19][C:18]1=[O:41]>>[CH:1]1([NH:4][C:37](=[O:38])[CH2:36][NH:35][C:24]2[N:25]=[C:26]([C:27]3[CH:32]=[CH:31][C:30]([F:33])=[CH:29][C:28]=3[CH3:34])[C:21]3[CH:20]=[CH:19][C:18](=[O:41])[N:17]([C:11]4[C:12]([F:16])=[CH:13][CH:14]=[CH:15][C:10]=4[F:9])[C:22]=3[N:23]=2)[CH2:3][CH2:2]1

참가 물질

4

반응물 3

HCID 69828CyclopropylamineHCID 16682925TrimethylaluminumHCID 59639612HCID 59639612, 화합물

생성물 1

HCID 59639540HCID 59639540, 화합물

실험 절차

Following the procedure outlined in Example 193, cyclopropylamine (0.23 mL, 3.3 mmol), trimethylaluminum (1.7 mL, 3.3 mmol) and the product of Example 190 (150 mg, 0.33 mmol) were reacted to give the desired product, 20 mg (13%). LC-MS: 480.0 (MH+, m/z), 1.89 (Rt, min).

출처 및 근거

ORD 기록
ord-c7c61eaed0e94e5a8ea4fea78e7f5027
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058282B2

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