Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Methyl 4-((1-(tert-butoxycarbonyl)piperidin-4-yl)methylamino)-6-chloronicotinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Boc-4-(aminomethyl)piperidine | HCID 736817 | — |
| 반응물 | Methyl4,6-dichloronicotinate | HCID 2764083 | — |
| 용매 | 1-Butanol | HCID 263 | — |
| 생성물 | Methyl 4-((1-(tert-butoxycarbonyl)piperidin-4-yl)methylamino)-6-chloronicotinate | HCID 59613527 | 84% |
반응 단계
A solution of methyl 4,6-dichloronicotinate (1.20 g, 5.8 mmol), tert-butyl 4-(aminomethyl)piperidine-1-carboxylate (1.24 g, 5.8 mmol) and triethylamine (4.09 mL, 29.1 mmol) in n-butanol (13 mL) was heated at 120° C. for 90 minutes by microwave irradiation. The solvent was evaporated and the mixture was purified by flash chromatography on silica, eluting with ethyl acetate-hexane (1:4), to give methyl 4-((1-(tert-butoxycarbonyl)piperidin-4-yl)methylamino)-6-chloronicotinate as a colourless solid (1.87 g, 84%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08058045B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-7bba965d4ae24c36b7b1fd041520abec |
| 출처 메모 | uspto-grants-2011_11 |