5-Amino-3-chloropyrazine-2-carbonitrile → 5-Amino-3-methoxypyrazine-2-carbonitrile

HRID 556881

반응식

HRID 556881 반응식
[NH2:1][C:2]1[N:3]=[C:4](Cl)[C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH3:11][O-:12].[Na+].CO>CO.O>[NH2:1][C:2]1[N:3]=[C:4]([O:12][CH3:11])[C:5]([C:8]#[N:9])=[N:6][CH:7]=1

참가 물질

5

반응물 2

HCID 210753925-Amino-3-chloropyrazine-2-carbonitrileHCID 23694274Sodium methanolate methanol

생성물 1

HCID 596133845-Amino-3-methoxypyrazine-2-carbonitrile수율 58%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

5-Amino-3-chloropyrazine-2-carbonitrile (52 mg, 0.34 mmol) was suspended in NaOMe/MeOH (2M, 2 mL). The reaction mixture was heated at 80° C. for 30 min using microwave irradiation. After cooling, the mixture was diluted with MeOH (3 mL) and water (2 mL). The solvents were concentrated and the resulting precipitate was filtered off, washed with water (3 mL) and dried in vacuo to give the title compound as a yellow solid (33 mg, 58%).

후처리

  1. custommicrowave irradiation
  2. temperatureAfter cooling
  3. concentrationThe solvents were concentrated
  4. filtrationthe resulting precipitate was filtered off
  5. washwashed with water (3 mL)
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-3225739478654ae88199617ad3e4528c
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058045B2

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