1-Boc-4-(3-nitro-5-trifluoromethyl-phenoxy)-piperidine → 1-Boc-4-(3-amino-5-trifluoromethyl-phenoxy)piperidine

HRID 557297노트

반응식

HRID 557297 반응식
[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([N+:25]([O-])=O)[CH:16]=2)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>CO.[Pd]>[C:1]([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[C:17]([NH2:25])[CH:16]=2)[CH2:10][CH2:9]1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]

참가 물질

4

반응물 1

HCID 219596141-Boc-4-(3-nitro-5-trifluoromethyl-phenoxy)-piperidine

생성물 1

HCID 219594191-Boc-4-(3-amino-5-trifluoromethyl-phenoxy)piperidine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1-Boc-4-(3-nitro-5-trifluoromethyl-phenoxy)-piperidine (470 mg) was dissolved in MeOH (12 ml) and Pd/C (10 mg) was added. After sparging briefly with H2, the mixture was stirred under H2 for 6H. The catalyst was removed by filtration and the MeOH solution was concentrated in vacuo to yield 1-Boc-4-(3-amino-5-trifluoromethyl-phenoxy)-piperidine as an off-white foam.

후처리

  1. customAfter sparging briefly with H2
  2. customThe catalyst was removed by filtration
  3. concentrationthe MeOH solution was concentrated in vacuo

출처 및 근거

ORD 기록
ord-62ee98c215624a738810fd89f1fec0e5
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058445B2

반응 노트

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