Ammonium Chloride → Tert-butyl 4-aminophenethylcarbamate

HRID 557348노트

반응식

HRID 557348 반응식
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH4+].[Cl-]>CCO.O.[Fe]>[NH2:17][C:14]1[CH:13]=[CH:12][C:11]([CH2:10][CH2:9][NH:8][C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])=[CH:16][CH:15]=1

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 10264884Tert-butyl N-[2-(4-nitrophenyl)ethyl]carbamate

생성물 1

HCID 382207Tert-butyl 4-aminophenethylcarbamate

시약·촉매·용매 3

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
80 °C

실험 절차

A mixture of (tert-butoxy)-N-[2-(4-nitrophenyl)ethyl]-carboxamide (570 mg, 2.15 mmol, Step A), iron powder (602 mg, 10.75 mmol) and NH4Cl (82 mg, 1.5 mmol) in EtOH (6 mL) and H2O (6 ml) was stirred for 4 h at 80° C. Filtration and concentration gave the crude compound, which was used in next step without further purification.

후처리

  1. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-882581988480452a9e786ff4ef262e6d
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058445B2

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