Acetyl chloride → 1-(6-Methoxy-2,2,4-trimethylquinolin-1(2H)-yl)ethan-1-one

HRID 557578노트

반응식

HRID 557578 반응식
[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12]([CH3:18])([CH3:17])[CH:11]=[C:10]2[CH3:19]>N1C=CC=CC=1>[C:1]([N:13]1[C:14]2[C:9](=[CH:8][C:7]([O:6][CH3:5])=[CH:16][CH:15]=2)[C:10]([CH3:19])=[CH:11][C:12]1([CH3:18])[CH3:17])(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 421426HCID 421426, 화합물

생성물 1

HCID 133701081-(6-Methoxy-2,2,4-trimethylquinolin-1(2H)-yl)ethan-1-one

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Acetyl chloride (8 ml) was added dropwise to a cooled (0° C.) solution of 1,2-dihydro-6-methoxy-2,2,4-trimethylquinoline (1.7 g) and a catalytic amount of N,N-dimethylaminopyridine in pyridine (60 ml). After stirring for 18 h, the reaction mixture was concentrated in vacuo. The residue was dissolved in dichloromethane and washed with 1 M HCl, water, 5% aq. NaHCO3, water and brine. The organic layer was dried (MgSO4) and concentrated in vacuo. The residue was chromatographed on silicagel in dichloromethane as eluent.

후처리

  1. concentrationthe reaction mixture was concentrated in vacuo
  2. dissolutionThe residue was dissolved in dichloromethane
  3. washwashed with 1 M HCl, water, 5% aq. NaHCO3, water and brine
  4. dry with materialThe organic layer was dried (MgSO4)
  5. concentrationconcentrated in vacuo
  6. customThe residue was chromatographed on silicagel in dichloromethane as eluent

출처 및 근거

ORD 기록
ord-96ce798c83d84b84ae4661e9d921f60b
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058441B2

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