Water → HCID 17962881, 화합물

HRID 557579노트

반응식

HRID 557579 반응식
B(Br)(Br)Br.[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([O:18]C)=[CH:15][CH:16]=2)[C:11]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([CH3:20])[CH2:10][C:9]1([CH3:28])[CH3:27])(=[O:7])[CH3:6].O>ClCCl>[C:5]([N:8]1[C:17]2[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=2)[C:11]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)([CH3:20])[CH2:10][C:9]1([CH3:28])[CH3:27])(=[O:7])[CH3:6]

참가 물질

5

반응물 3

HCID 962WaterHCID 25134Boron tribromideHCID 17962883HCID 17962883, 화합물

생성물 1

HCID 17962881HCID 17962881, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Boron tribromide (1.30 ml) was added dropwise to a cooled (0° C.) solution of 1-acetyl-6-methoxy-4-phenyl-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline (0.9 g) in dichloromethane (75 ml). After stirring for 18 h, the reaction mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with water, 5% aq. NaHCO3 and water, dried (MgSO4) and concentrated in vacuo.

후처리

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water, 5% aq. NaHCO3 and water
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-01ea5e89875a426284cdf93c8a3d7617
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08058441B2

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