참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 반응물 | Methyl acetyl(p-bromobenzoyl)acetate | HCID 603116 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | Methyl 5-(4-bromophenyl)-3-methylisoxazole-4-carboxylate | HCID 56604575 | — |
반응 단계
2-(4-Bromo-benzoyl)-3-oxo-butyric acid methyl ester (11 g, 39 mmol) and hydroxylamine hydrochloride (2.66 g, 39 mmol) were combined in acetic acid (50 mL), and the reaction was stirred at 115° C. for 1 hour. After cooling, aqueous work-up gave the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08058300B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_11 |
|---|
| ORD ID | ord-0e484f1de3224db0916b7d72db495d28 |
|---|
| 출처 메모 | uspto-grants-2011_11 |
|---|
