Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 6-Bromo-1-benzothiophene-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 6-Bromo-benzo[b]thiophene-2-carboxylic acid methyl ester | HCID 22474078 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 6-Bromo-1-benzothiophene-2-carboxylic acid | HCID 13567980 | — |
반응 단계
A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50° C. 3.55 g (93.5% of theory) of the desired product are obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09433614B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-195c3d7f9ab44d679c042dadfc5e6873 |
| 출처 메모 | uspto-grants-2016_09 |