Potassium Hydroxide → 6-Bromo-1-benzothiophene-2-carboxylic acid

HRID 55771

반응식

HRID 55771 반응식
[Br:1][C:2]1[CH:14]=[CH:13][C:5]2[CH:6]=[C:7]([C:9]([O:11]C)=[O:10])[S:8][C:4]=2[CH:3]=1.[OH-].[K+]>C1COCC1>[Br:1][C:2]1[CH:14]=[CH:13][C:5]2[CH:6]=[C:7]([C:9]([OH:11])=[O:10])[S:8][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 224740786-Bromo-benzo[b]thiophene-2-carboxylic acid methyl ester

생성물 1

HCID 135679806-Bromo-1-benzothiophene-2-carboxylic acid

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4.0 g (14.8 mmol) of methyl 6-bromo-1-benzothiophene-2-carboxylate in 40 ml of a 1:1 mixture of THF and 2 N potassium hydroxide solution is stirred at room temperature for 2 h. The solvent is removed in vacuo, and the residue is acidified with concentrated hydrochloric acid. The resulting precipitate is filtered off with suction, washed with water and dried in vacuo at 50° C. 3.55 g (93.5% of theory) of the desired product are obtained.

후처리

  1. customThe solvent is removed in vacuo
  2. filtrationThe resulting precipitate is filtered off with suction
  3. washwashed with water
  4. customdried in vacuo at 50° C

출처 및 근거

ORD 기록
ord-195c3d7f9ab44d679c042dadfc5e6873
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09433614B2

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