Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | Pentafluorophenol | HCID 13041 | — |
| 반응물 | 2-(Quinuclidin-3-yl)acetic acid hydrochloride | HCID 23024147 | — |
| 촉매 | Diisopropylethylamine | HCID 81531 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Pentafluorophenyl (1-azabicyclo[2.2.2]oct-3-yl)acetate hydrochloride | HCID 86610796 | — |
반응 단계
358 mg (1.94 mmol) of pentafluorophenol, 120.5 mg (0.63 mmol) of EDC and 1 drop of N,N-diisopropylethylamine are added to a solution of 100 mg (0.49 mmol) of 1-azabicyclo[2.2.2]oct-3-ylacetic acid hydrochloride in 4 ml of dichloromethane at 0° C. The mixture is stirred at room temperature for 18 h. The contents of the flask are concentrated in vacuo and dried under high vacuum. The resulting crude product is employed without further purification in the following stages.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09433614B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-b3b1aaa0e07f4281b55d14c723e1b6a1 |
| 출처 메모 | uspto-grants-2016_09 |