Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-6-methoxyquinoline → 4-(6-Hydroxyquinolin-2-yl)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-6-methoxyquinoline | HCID 83647 | — |
| 반응물 | 4-Methoxycarbonylphenylboronic acid | HCID 2734369 | — |
| 생성물 | 4-(6-Hydroxyquinolin-2-yl)benzoic acid | HCID 56960775 | — |
반응 단계
Followed Scheme 2, A conditions: Starting materials: 2-chloro-6-methoxyquinoline (Intermediate 1) (100 mg, 0.52 mmol) and (4-(methoxycarbonyl)phenyl) boronic acid. 1H NMR (DMSO-d6, 400 MHz): δ 13.06-12.90 (bs, 1H), 10.14 (s, 1H), 8.36-8.33 (d, 2H), 8.30-8.27 (d, 1H), 8.11-8.06 (m, 3H), 7.97-7.94 (d, 1H), 7.38-7.34 (dd, 1H), 7.20 (s, 1H). MS (ESI): m/z 266.08 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09433618B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-51b85ec2ac804e558132019fe4421e59 |
| 출처 메모 | uspto-grants-2016_09 |