Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Carboxy-3-fluorophenylboronic acid → 2-Fluoro-4-(6-hydroxyquinolin-2-yl)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Carboxy-3-fluorophenylboronic acid | HCID 2763201 | — |
| 반응물 | 2-Chloroquinolin-6-ol | HCID 22132577 | — |
| 생성물 | 2-Fluoro-4-(6-hydroxyquinolin-2-yl)benzoic acid | HCID 56960914 | — |
반응 단계
Followed Scheme 3: Starting Materials: 2-chloroquinolin-6-ol (Intermediate 2) and 4-borono-2-fluorobenzoic acid. 1H NMR (CD3OD, 400 MHz): δ 8.54 (d, J=8.4 Hz, 1H), 8.20-8.06 (m, 3H), 8.06-7.96 (m, 2H), 7.55 (dd, J=9.2, 2.4 Hz, 1H), 7.32 (d, J=2.8 Hz, 1H). MS (ESI): m/z 283.6 [M+1]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09433618B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-fdc47d94f1cb47239575a8bc12e2a82d |
| 출처 메모 | uspto-grants-2016_09 |