4-Carboxy-3-fluorophenylboronic acid → 2-Fluoro-4-(6-hydroxyquinolin-2-yl)benzoic acid

HRID 55787

반응식

HRID 55787 반응식
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([OH:12])[CH:8]=2)[N:3]=1.B([C:16]1[CH:24]=[CH:23][C:19]([C:20]([OH:22])=[O:21])=[C:18]([F:25])[CH:17]=1)(O)O>>[F:25][C:18]1[CH:17]=[C:16]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([OH:12])[CH:8]=3)[N:3]=2)[CH:24]=[CH:23][C:19]=1[C:20]([OH:22])=[O:21]

참가 물질

3

반응물 2

HCID 27632014-Carboxy-3-fluorophenylboronic acidHCID 221325772-Chloroquinolin-6-ol2회

생성물 1

HCID 569609142-Fluoro-4-(6-hydroxyquinolin-2-yl)benzoic acid

실험 절차

Followed Scheme 3: Starting Materials: 2-chloroquinolin-6-ol (Intermediate 2) and 4-borono-2-fluorobenzoic acid. 1H NMR (CD3OD, 400 MHz): δ 8.54 (d, J=8.4 Hz, 1H), 8.20-8.06 (m, 3H), 8.06-7.96 (m, 2H), 7.55 (dd, J=9.2, 2.4 Hz, 1H), 7.32 (d, J=2.8 Hz, 1H). MS (ESI): m/z 283.6 [M+1]+.

출처 및 근거

ORD 기록
ord-fdc47d94f1cb47239575a8bc12e2a82d
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09433618B2

연결된 노트

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