Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 5-Bromo-N-cyclopropylpyridine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Cyclopropylamine | HCID 69828 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| 반응물 | 5-Bromopyridine-2-carboxylic acid | HCID 608544 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-Bromo-N-cyclopropylpyridine-2-carboxamide | HCID 26370089 | — |
반응 단계
N,N-Diisopropylethylamine (0.69 mL, 0.0040 mol) was added to a mixture of 5-bromopyridine-2-carboxylic acid (400 mg, 0.002 mol), cyclopropylamine (0.16 mL, 0.0024 mol) and benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (1.1 g, 0.0024 mol) in N,N-dimethylformamide (9.4 mL, 0.12 mol) at 0° C. and the mixture was stirred overnight at room temperature. The mixture was diluted with ethyl acetate, washed with water and brine successively, dried over sodium sulfate, filtered and concentrated. The product was purified by CombiFlash eluting with CH2Cl2/EtOAc (max.EtOAc 20%). LC-MS: 241.1/243.1 (M+H+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08058288B2 |
| 출처 데이터셋 | uspto-grants-2011_11 |
| ORD ID | ord-608f3976613242cc85a4cb23aedc7b10 |
| 출처 메모 | uspto-grants-2011_11 |