Borane;tetrahydrofuran → 2-(2-Bromo-4-fluorophenyl)-2-methylpropan-1-amine

HRID 558116노트

반응식

HRID 558116 반응식
B.C1COCC1.[Br:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[C:15]([CH3:19])([CH3:18])[C:16]#[N:17]>C1COCC1>[Br:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[C:15]([CH3:19])([CH3:18])[CH2:16][NH2:17]

참가 물질

4

반응물 2

HCID 2723981Borane;tetrahydrofuranHCID 574450632-(2-Bromo-4-fluorophenyl)-2-methylpropanenitrile

생성물 1

HCID 574450652-(2-Bromo-4-fluorophenyl)-2-methylpropan-1-amine수율 99%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Add borane-THF complex (2 M in THF, 10 mL, 20 mmol) to a stirred solution of 2-(2-bromo-4-fluoro-phenyl)-2-methyl-propionitrile (0.8 g, 3.30 mmol) in 10 mL of THF at 0° C. Stir the mixture at 0° C. to RT over the weekend. Quench the reaction with diluted ammonium hydroxide. Extract the product with chloroform. Dry the organic phase over sodium sulfate and concentrate to give the title compound (0.8 g, 99%). MS (ES) m/z 246/248 [M+1]+.

후처리

  1. customQuench
  2. customthe reaction with diluted ammonium hydroxide
  3. extractionExtract the product with chloroform
  4. dry with materialDry the organic phase over sodium sulfate
  5. concentrationconcentrate

출처 및 근거

ORD 기록
ord-e0a86ba2cea449d8aaf894b0330cb5f9
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063035B2

반응 노트

불러오는 중…