Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 5-(6-Hydroxyquinolin-2-yl)thiophene-2-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2-Chloro-6-methoxyquinoline | HCID 83647 | — |
| 반응물 | 5-Cyanothiophene-2-boronic acid | HCID 4198743 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 5-(6-Hydroxyquinolin-2-yl)thiophene-2-carbonitrile | HCID 66980042 | — |
반응 단계
Followed the two step synthesis shown in Scheme 1 starting with 2-chloro-6-methoxyquinoline and 5-cyanothiophen-2-ylboronic acid, with minor variations: the base used in step 1 was sodium carbonate and the solvent was DME (dimethoxyethane)/water. In step 2, after quenching w/ice water, a standard ethyl acetate extraction was preformed followed by purification by prep-TLC (PE: EA=1:1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09433618B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-142f8f3882e1471e8bb723a571b8afe9 |
| 출처 메모 | uspto-grants-2016_09 |