Bromine → Methyl 4-(5-bromo-6-methoxyquinolin-2-yl)benzoate

HRID 55820노트

반응식

HRID 55820 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([C:13]1[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=1)[CH:7]=[CH:6]2.[Br:23]Br>C(Cl)Cl>[Br:23][C:4]1[C:3]([O:2][CH3:1])=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8]([C:13]1[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=1)=[N:9]2

참가 물질

4

반응물 2

HCID 24408BromineHCID 66980098Methyl 4-(6-methoxyquinolin-2-yl)benzoate

생성물 1

HCID 66980100Methyl 4-(5-bromo-6-methoxyquinolin-2-yl)benzoate수율 100%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of methyl 4-(6-methoxyquinolin-2-yl)benzoate (630 mg, 2.15 mmol) in DCM (9 mL) was added Br2 (0.3 mL, 6.45 mmol). The reaction mixture was stirred at room temperature overnight. Then the mixture was partitioned with brine and DCM. The precipitate was filtered and dried to give the product as a solid (800 mg, 100%). MS (ESI): m/z=373.0 [M+1]+.

후처리

  1. customThen the mixture was partitioned with brine and DCM
  2. filtrationThe precipitate was filtered
  3. customdried

출처 및 근거

ORD 기록
ord-37afd7fc6b4b45b6b8ad9511631fe136
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09433618B2

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