참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 2-Chloro-3-quinolinecarboxaldehyde | HCID 690958 | — |
| 반응물 | Azane;hydrate | HCID 12896473 | — |
| 생성물 | 2-Chloro-6-methoxyquinoline-3-carbonitrile | HCID 865612 | 38% |
반응 단계
To a mixture of 2-chloroquinoline-3-carboxaldehyde (1.00 g, 4.50 mmol) in THF (30 mL) was added NH3.H2O (30 mL, 25%) and I2 (1.26 g, 4.90 mmol), the mixture was stirred at 20° C. for 8 hours. Aqueous workup with EtOAc extraction gave the crude product. Purification by silica gel column (PE/EtOAc=10/1 to 2/1) gave the product (370 mg, yield 38%) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09433618B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-22a2dad257f1404186296a5281e81c61 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
