Ammonia → 3-Cyanobenzamide
반응식
[NH3:1].[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](Cl)=[O:8])#[N:3]>ClCCl>[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH2:1])=[O:8])#[N:3]참가 물질
4
실험 절차
0.88 Ammonia solution (30 ml) was slowly added to a solution of 3-cyanobenzoyl chloride (10 g, 60.3 mmol) in dichloromethane (100 ml) at 0° C. under nitrogen and the reaction was stirred for 20 minutes. The mixture was filtered and the solid was washed with water (50 ml) then diethylether (50 ml), azeotroped with toluene and dried in vacuo to provide the title compound (9 g) as a white solid.
후처리
- filtrationThe mixture was filtered
- washthe solid was washed with water (50 ml)
- customdiethylether (50 ml), azeotroped with toluene
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-f90883a111af416d9a39944da9a1fccb
- 출처 데이터셋
- uspto-grants-2011_11
- 특허 번호
- US08063044B2
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