Ammonia → 3-Cyanobenzamide

HRID 558317

반응식

HRID 558317 반응식
[NH3:1].[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](Cl)=[O:8])#[N:3]>ClCCl>[C:2]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([NH2:1])=[O:8])#[N:3]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 3084833-Cyanobenzoyl chloride

생성물 1

HCID 769743-Cyanobenzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

0.88 Ammonia solution (30 ml) was slowly added to a solution of 3-cyanobenzoyl chloride (10 g, 60.3 mmol) in dichloromethane (100 ml) at 0° C. under nitrogen and the reaction was stirred for 20 minutes. The mixture was filtered and the solid was washed with water (50 ml) then diethylether (50 ml), azeotroped with toluene and dried in vacuo to provide the title compound (9 g) as a white solid.

후처리

  1. filtrationThe mixture was filtered
  2. washthe solid was washed with water (50 ml)
  3. customdiethylether (50 ml), azeotroped with toluene
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-f90883a111af416d9a39944da9a1fccb
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063044B2

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