Triethylamine → HCID 25071457, 화합물

HRID 558452

반응식

HRID 558452 반응식
C1CN([P+](ON2N=NC3C=CC=CC2=3)(N2CCCC2)N2CCCC2)CC1.F[P-](F)(F)(F)(F)F.Cl.Cl.[NH2:36][C:37]1[N:45]=[C:44]([O:46][CH2:47][CH2:48][CH2:49][CH3:50])[N:43]=[C:42]2[C:38]=1[NH:39][C:40](=[O:62])[N:41]2[CH2:51][CH2:52][CH2:53][NH:54][CH2:55][C:56]1[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=1.CCN(CC)CC.[CH3:70][O:71][C:72](=[O:78])[CH2:73][CH2:74][C:75](O)=[O:76]>CN(C=O)C.CO>[NH2:36][C:37]1[N:45]=[C:44]([O:46][CH2:47][CH2:48][CH2:49][CH3:50])[N:43]=[C:42]2[C:38]=1[NH:39][C:40](=[O:62])[N:41]2[CH2:51][CH2:52][CH2:53][N:54]([CH2:55][C:56]1[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=1)[C:75](=[O:76])[CH2:74][CH2:73][C:72]([O:71][CH3:70])=[O:78]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 77487monoMethyl succinateHCID 2724699PyBOPHCID 1317292856-Amino-9-[3-(benzylamino)propyl]-2-butoxy-7,9-dihydro-8H-purin-8-one, dihydrochloride

생성물 1

HCID 25071457HCID 25071457, 화합물

시약·촉매·용매 2

HCID 887Methanol용매HCID 6228Dimethylformamide용매

실험 절차

PyBop (0.47 g) was added to a mixture of the product from example 1 step (viii) (0.25 g), Et3N (0.7 ml) and succinic acid monomethyl ester (0.16 g) in DMF (8 ml) and stirred at rt for 4 days. MeOH (10 ml) was added, the solvent evaporated under reduced pressure and the residue purified by RPHPLC, yield 46 mg.

후처리

  1. customthe solvent evaporated under reduced pressure
  2. customthe residue purified by RPHPLC, yield 46 mg

출처 및 근거

ORD 기록
ord-01bd19a3c14b44299feb915fed82f286
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08063051B2

연결된 노트

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