Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Chloropropionyl chloride → 3-chloro-N-(2-fluoro-4-hydroxyphenyl)propanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Chloropropionyl chloride | HCID 69364 | — |
| 반응물 | 4-Amino-3-fluorophenol | HCID 2735919 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 3-chloro-N-(2-fluoro-4-hydroxyphenyl)propanamide | HCID 66980071 | 50.7% |
반응 단계
4-Amino-3-fluorophenol (3.4 g) was mixed with 3-chloropropanoyl chloride (3.56 g) in acetone (60 mL) and heated at reflux over 3 hours. After aqueous work-up with EtOAc/water, the isolated organic layers were dried over Na2SO4 and concentrated in vacuo. The crude product was purified with silica gel chromatography to give the product (2.95 g) as a light brown solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09433618B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-2e11691e25a74dbe9424770cd4a8d518 |
| 출처 메모 | uspto-grants-2016_09 |