Tert-Butylamine → 3-Bromo-N-tert-butylbenzene-1-sulfonamide

반응식

[C:1]([NH2:5])([CH3:4])([CH3:3])[CH3:2].[Br:6][C:7]1[CH:8]=[C:9]([S:13](Cl)(=[O:15])=[O:14])[CH:10]=[CH:11][CH:12]=1>>[Br:6][C:7]1[CH:8]=[C:9]([S:13]([NH:5][C:1]([CH3:4])([CH3:3])[CH3:2])(=[O:15])=[O:14])[CH:10]=[CH:11][CH:12]=1

참가 물질

반응물 2

HCID 6385Tert-Butylamine

HCID 17943m-Bromobenzenesulphonyl chloride

생성물 1

HCID 48209263-Bromo-N-tert-butylbenzene-1-sulfonamide수율 106.4%

실험 절차

Prepared by general procedure III from tert-butylamine (3.16 mL, 30 mmol) and commercially available 3-bromobenzenesulfonyl chloride (1.44 mL, 10 mmol) to give the title compound as a light yellow solid (3.11 g, 106%). MS (ISN) 290.1 [(M−H)−], 292.2 [(M+2−H)−].

출처 및 근거

ORD 기록: ord-e123073eecd6444fb5e6d4ff93eb615b
출처 데이터셋: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08063048B2

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